hrp0089fc8.6 | Sex differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2018

The Roles of Steroids in Gonadal Development and Maintenance – Insights from a Zebrafish Model of Androgen and Cortisol Deficiency

Oakes James A. , Li Nan , Wistow Belinda , Storbeck Karl-Heinz , Cunliffe Vincent T. , Krone Nils

Increasing evidence suggests that the aetiology of disorders of sex development cannot be solely explained by genetic alterations. It is highly likely that environmental factors hitting susceptible genetic backgrounds are partly causative. Zebrafish sex is highly plastic during development, making this species an ideal model for investigation of endocrine disruption and gonadal development and function. However, the hormonal regulation of these processes in zebrafish is poorly...